Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and
Citrus hystrix (Rutaceae) are edible plants that are commonly used as flav
ors or condiments in various Thai food dishes. They are known to exert stro
ng anti-promoting activity in a test of tumor promoter-induced Epstein-Barr
virus (EBV) activation. In the present study their effects on hepatocarcin
ogeness were investigated in a medium-term bioassay using F344 male rats. C
. hystrix significantly enhanced 2-amino-3,8-dimethylimidazo(4-5-f)quinox p
reneoplastic liver cell focus development while B. pandurata and L, galanga
had borderline effects. The results suggest that C. hystrix as well as B.
pandurata and L. galanga may contain agents augmenting the hepatocarcinogen
icity of 2-amino-3,8-dimerhylimidazo(4,5-f)quinox (C) 2000 Elsevier Science
Ireland Ltd. All rights reserved.