Enhancing effects of Thai edible plants on 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay

Citation
D. Tiwawech et al., Enhancing effects of Thai edible plants on 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay, CANCER LETT, 158(2), 2000, pp. 195-201
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
158
Issue
2
Year of publication
2000
Pages
195 - 201
Database
ISI
SICI code
0304-3835(20001001)158:2<195:EEOTEP>2.0.ZU;2-N
Abstract
Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and Citrus hystrix (Rutaceae) are edible plants that are commonly used as flav ors or condiments in various Thai food dishes. They are known to exert stro ng anti-promoting activity in a test of tumor promoter-induced Epstein-Barr virus (EBV) activation. In the present study their effects on hepatocarcin ogeness were investigated in a medium-term bioassay using F344 male rats. C . hystrix significantly enhanced 2-amino-3,8-dimethylimidazo(4-5-f)quinox p reneoplastic liver cell focus development while B. pandurata and L, galanga had borderline effects. The results suggest that C. hystrix as well as B. pandurata and L. galanga may contain agents augmenting the hepatocarcinogen icity of 2-amino-3,8-dimerhylimidazo(4,5-f)quinox (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.