Cocaine catalytic antibodies: The primary importance of linker effects

Citation
M. Matsushita et al., Cocaine catalytic antibodies: The primary importance of linker effects, BIOORG MED, 11(2), 2001, pp. 87-90
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
87 - 90
Database
ISI
SICI code
0960-894X(20010122)11:2<87:CCATPI>2.0.ZU;2-O
Abstract
Current treatments for cocaine addiction are not effective. The development of a catalytic monoclonal antibody (mAb) provides a strategy for not only binding, but also degrading cocaine, which offers a broad-based therapy. Ha pten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analogue pho sphonate haptens were shown to be important for obtaining mAbs that hydroly ze the benzoate eater of cocaine. (C) 2001 Elsevier Science Ltd. All rights reserved.