Nine novel single-nucleotide polymorphisms in the integrin beta 4 (ITGB4) gene in the Japanese population

Citation
A. Hirano et al., Nine novel single-nucleotide polymorphisms in the integrin beta 4 (ITGB4) gene in the Japanese population, J HUM GENET, 46(1), 2001, pp. 35-37
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
JOURNAL OF HUMAN GENETICS
ISSN journal
1434-5161 → ACNP
Volume
46
Issue
1
Year of publication
2001
Pages
35 - 37
Database
ISI
SICI code
1434-5161(2001)46:1<35:NNSPIT>2.0.ZU;2-D
Abstract
We identified nine single-nucleotide polymorphisms (SNPs) in the human inte grin (beta4 (ITGB4) gene (17q24-q25), which encodes a cell-surface receptor , by screening all exons and exon-intron boundaries. Seven of these SNPs we re present in coding regions and two in intronic sequences; four of the cod ing SNPs involved amino-acid substitutions. As the gene is implicated in th e tumorigenesis of breast cancers, the polymorphic sites will serve as usef ul markers not only for distinguishing alleles in loss of heterozygosity (L OH) analyses but also for studying genetic susceptibility to malignancies i n humans.