Role of structural complexities of septal tissue in maintaining ventricular fibrillation in isolated, perfused canine ventricle

Citation
T. Ikeda et al., Role of structural complexities of septal tissue in maintaining ventricular fibrillation in isolated, perfused canine ventricle, J CARD ELEC, 12(1), 2001, pp. 66-75
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
ISSN journal
1045-3873 → ACNP
Volume
12
Issue
1
Year of publication
2001
Pages
66 - 75
Database
ISI
SICI code
1045-3873(200101)12:1<66:ROSCOS>2.0.ZU;2-K
Abstract
Tissue Structure and VF. Introduction: It is unclear how the patterns of wa velet propagation during ventricular fibrillation (VF) vary between structu rally different tissues. We hypothesized that the structural complexities o f septal tissue influence the maintenance of reentrant wavelets in the vent ricle. Methods and Results: Endocardial activation patterns during VF were analyze d in the isolated, perfused canine right ventricular (RV) free wall (n = 9) , interventricular septum (n = 5), and left ventricular (LV) free wall (n = 6) using a computerized mapping system (2-mm resolution) with 120-msec con secutive windows. Each tissue sample was cut progressively to reduce the ti ssue mass until the VF was terminated. More wavelets were seen in the septa than in the RV and LV free walls at baseline (P = 0.004), and VF in the se pta displayed a shorter cycle length than in the RV and LV free walls (P = 0.017). As the tissue mass decreased, VF became successively more organized in all regions: the number of wavelets decreased and the cycle length of V F lengthened. Single and "figure-of-eight" stationary, reentrant wavelets o ften were mapped after tissue mass reduction in the RV free walls and rarel y in the LV free walls, but they were not observed in the septa, Less criti cal mass was required to maintain VF in the septa than in the RV and LV fre e walls (P = 0.0006). Gross anatomic and histologic examinations indicated that the tissue structure of the septa is more complex than that of the RV and LV free walls. Conclusion: VF activation patterns with progressive reduction of tissue mas s differ for the septum and the ventricular free walls. The structural comp lexities of the septal tissue influence the maintenance of fibrillation in the ventricle.