Prognostic importance of the nucleolar organizer region score in ovarian epithelial tumors

Citation
S. Zergeroglu et al., Prognostic importance of the nucleolar organizer region score in ovarian epithelial tumors, GYNECOL OBS, 51(1), 2001, pp. 60-63
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
60 - 63
Database
ISI
SICI code
0378-7346(2001)51:1<60:PIOTNO>2.0.ZU;2-5
Abstract
Objective: The score of the silver-stained nucleolar organizer region (AgNO R) is frequently found to be high in malignant tumors. We studied AgNOR in ovarian epithelial tumors diagnosed in our hospital between 1993 and 1998. Materials and Method: In our study 67 ovarian epithelial tumors (18 cystade noma, 16 borderline type, 34 cystadenocarcinoma) were stained using the met hod previously described by Crocker. One-way ANOVA and logistic regression tests were used to find the statistical relationship between grade, recurre nce, mortality rates and AgNOR scores in tumors (p values of <0.05 were con sidered statistically significant). Results: The mean AgNOR scores of 28 mu cinous and 39 serous ovary tumors were calculated. The lowest AgNOR score o f 1.33 was found in cystadenomas and the highest AgNOR score of 4.92 was fo und in serous and mucinous cystadenocarcinomas. In addition the relationshi p between mortality rate, recurrence and AgNOR score in carcinomas were stu died. Conclusion: AgNOR scores in carcinomas were found to be higher than a denomas, and the highest AgNOR score was found in grade-ill carcinomas. Thi s shows that the AgNOR score can be used as a prognostic index in malignanc ies. Copyright (C) 2001 S. Karger AG, Basel.