Endocrine and metabolic effects of insulin sensitizers in the treatment ofpatients with polycystic ovary syndrome and hyperinsulinaemia

Citation
L. Ciotta et al., Endocrine and metabolic effects of insulin sensitizers in the treatment ofpatients with polycystic ovary syndrome and hyperinsulinaemia, GYNECOL OBS, 51(1), 2001, pp. 44-50
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
44 - 50
Database
ISI
SICI code
0378-7346(2001)51:1<44:EAMEOI>2.0.ZU;2-W
Abstract
We evaluated 16 women with polycystic ovary syndrome (PCOS) and 67 controls , aged 18-34 years. All subjects had an oral glucose tolerance test (OGTT), showing a normal response. They were subdivided into 2 groups (normoinsuli naemic, hyperinsulinaemic) undergoing 7 days of octreotide treatment. This caused modifications in body mass index, waist-hip ratio and blood pressure . No modifications were observed in basal luteinizing hormone (LH), follicl e-stimulating hormone, androgens, 17 alpha -hydroxyprogesterone, oestradiol , sex-hormone-binding globulin (SHBG), prolactin and cortisol serum concent rations in normoinsulinaemic patients. A significant decrease in the concen tration of LH, androgens, and a significant increase in SHBG were observed in the hyperinsulinaemic patients. In hyperinsulinaemic pensation of the gl ycaemic response was observed. Several agents (insulin sensitizers) decreas e insulin secretion and androgen concentration. They could be considered an approachable long-term therapy for hyperinsulinaemic hyperandrogenic patie nts. In the next few years the pharmacotherapy for PCOS could be greatly ex panded, allowing some patients, such as hyperinsulinaemic ones, to be treat ed with insulin sensitizers. Copyright (C) 2001 S. Karger AG,Basel.