Case-control study on risk factors for premature ovarian failure

Citation
G. Testa et al., Case-control study on risk factors for premature ovarian failure, GYNECOL OBS, 51(1), 2001, pp. 40-43
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
40 - 43
Database
ISI
SICI code
0378-7346(2001)51:1<40:CSORFF>2.0.ZU;2-Z
Abstract
Objective of this case-control study was to investigate the potential risk factors for premature ovarian failure (POF). Seventy-three patients with se condary hypergonadotropic amenorrhea and, as control group, 144 women with acute, non-gynecological, non-neoplastic, non-hormone-related diseases were included in the study. Information was obtained on sociodemographic charac teristics, gynecological and obstetric data, general life-stile habits, smo king habits and history of selected gynecological and other clinical condit ions. A statistically significant association between high education level and POF was found (p = 0.03). Parity was related to a reduced risk of POF a nd this reduction increased with the number of live births (p = 0.02). No a ssociation emerged between POF risk and age at menarche, cycle length and o ral contraceptive use. Women with POF could not be distinguished from contr ol women by behavioral and reproductive history, except for lower fertility . The minor influence that reproductive and lifestyle factors have on the o ccurrence of POF suggests that genetic inheritance plays a more important r ole. Copyright (C) 2001 S. Karger AG, Basel.