Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia

Citation
T. Takeuchi et al., Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia, GYNECOL OBS, 51(1), 2001, pp. 36-39
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
0378-7346 → ACNP
Volume
51
Issue
1
Year of publication
2001
Pages
36 - 39
Database
ISI
SICI code
0378-7346(2001)51:1<36:ROPAIV>2.0.ZU;2-S
Abstract
The aim of this study was to evaluate the possible role of plasma adenosine in platelet aggregation in preeclampsia, We measured the plasma adenosine concentration [ADO] and in vitro platelet aggregation in the third trimeste r of normal pregnant (n = 15) and preeclamptic women (n = 15), The mean pla sma [ADO] in preeclampsia was 0.68 +/- 0.08 muM (means +/- SEM), significan tly higher than in normal pregnancy (0.42 +/- 0.09 muM) (p < 0.05). In pree clampsia, platelet aggregation in response to collagen was approximately 40 % lower than that in norma I pregnancy (p < 0.05). There was a n inverse co rrelation between the plasma [ADO] and platelet aggregation in vitro (r = - 0.27, p < 0.05). These results suggest reduced platelet aggregation in pree clampsia may be at least in part attributed to an elevation of the the plas ma [ADO], Copyright (C) 2001 S. Karger AG, Basel.