Objective: To investigate the clinical use of p53 autoantibodies as a marke
r in the postoperative monitoring of colorectal cancer.
Design: Retrospective study.
Setting: Teaching hospital, Japan. Subjects: 40 patients with colorectal ca
ncer who had p53 autoantibodies in their serum preoperatively. Intervention
s: Serial assay of p53 autoantibodies by ELISA before and after resection.
Main outcome measures: Interpretation by a qualitative analysis.
Results: A significant correlation was observed between curability by surgi
cal resection and postoperative disappearance of p53 autoantibodies. Twenty
-seven (96%) of 28 patients, who had p53 autoantibodies and whose cancer wa
s completely removed, had no such antibodies after resection and no recurre
nce after 7 to 26 months.
Conclusions: Postoperative assays of p53 autoantibodies are potentially use
ful for predicting recurrence of colorectal cancer in patients who have p53