Monitoring of p53 autoantibodies after resection of colorectal cancer: Relationship to operative curability

Citation
A. Takeda et al., Monitoring of p53 autoantibodies after resection of colorectal cancer: Relationship to operative curability, EURO J SURG, 167(1), 2001, pp. 50-53
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
EUROPEAN JOURNAL OF SURGERY
ISSN journal
1102-4151 → ACNP
Volume
167
Issue
1
Year of publication
2001
Pages
50 - 53
Database
ISI
SICI code
1102-4151(200101)167:1<50:MOPAAR>2.0.ZU;2-M
Abstract
Objective: To investigate the clinical use of p53 autoantibodies as a marke r in the postoperative monitoring of colorectal cancer. Design: Retrospective study. Setting: Teaching hospital, Japan. Subjects: 40 patients with colorectal ca ncer who had p53 autoantibodies in their serum preoperatively. Intervention s: Serial assay of p53 autoantibodies by ELISA before and after resection. Main outcome measures: Interpretation by a qualitative analysis. Results: A significant correlation was observed between curability by surgi cal resection and postoperative disappearance of p53 autoantibodies. Twenty -seven (96%) of 28 patients, who had p53 autoantibodies and whose cancer wa s completely removed, had no such antibodies after resection and no recurre nce after 7 to 26 months. Conclusions: Postoperative assays of p53 autoantibodies are potentially use ful for predicting recurrence of colorectal cancer in patients who have p53 autoantibodies preoperatively.