Neutrophilia and granulocyte colony-stimulating factor levels after cardiopulmonary bypass

Citation
H. Iwasaka et al., Neutrophilia and granulocyte colony-stimulating factor levels after cardiopulmonary bypass, CAN J ANAES, 48(1), 2001, pp. 81-84
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
ISSN journal
0832-610X → ACNP
Volume
48
Issue
1
Year of publication
2001
Pages
81 - 84
Database
ISI
SICI code
0832-610X(200101)48:1<81:NAGCFL>2.0.ZU;2-M
Abstract
Purpose: The precise mechanism of neutrophilia after cardiac surgery is unk nown. Granulocyte colony stimulating factor (G-CSF) can increase the number of leukocytes. The purpose of this study was to evaluate the relationship between serum G-CSF levels and peripheral blood leukocyte counts after card iac surgery. Methods: We prospectively studied 10 patients undergoing cardiac surgery (c oronary artery bypass grafting) using cardiopulmonary bypass (CPB). Plasma G-CSF levels and neutrophil count were measured before induction of anaesth esia, at the end of surgery, and on the first postoperative day. These chan ges were compared with those in patients undergoing non-cardiac major surge ry (control group). Results: At the end of surgery, G-CSF levels increased (P < 0.01) in both g roups, but were higher in the control than in the cardiac group (3,250 +/- 690 vs 194 +/- 29.5 pg.ml(-1), respectively, mean +/- SEM, P < 0.01). On th e first postoperative day, G-CSF levels were still high in both groups, and were still higher in the control (7 10 +/- 179 vs 122 +/- 19,9, respective ly, P < 0.0 1). However, neutrophilia was greater in the cardiac group than in the control. G-CSF response correlated positively with neutrophilia in the control group (r=0.656, P < 0.05) but not in the cardiac group. Conclusions: Our results indicate that changes in leukocyte count following cardiac surgery are unique to patients undergoing CPB. G-CSF plays an impo rtant role as the mediator of neutrophilia after non-cardiac surgery, but n ot after cardiac surgery with CPB.