Spontaneous reconstruction of the canine hypogastric nerve over a long period after removing half of its length

T. Kobayashi et al., Spontaneous reconstruction of the canine hypogastric nerve over a long period after removing half of its length, AUTON NEURO, 86(3), 2001, pp. 151-162
Citations number
Categorie Soggetti
Neurosciences & Behavoir
Journal title
ISSN journal
1566-0702 → ACNP
Year of publication
151 - 162
SICI code
Spontaneous reconstruction of the sympathetic pathway projecting to the sem inal tract after serious injury has not been well understood. Multiple cros s-innervation mechanisms fi om the spinal cord via the hypogastric ner-ve t o the seminal tract have been demonstrated currently. This study was undert aken to explore long-term spontaneous reconstruction of the canine hypogast ric nerve (HGN), which controls ejaculation, after removing half of its len gth. Further, the study tried to identify the crossed-pathway(s) reconstruc ted Responses of the vas deferens/epididymis and bladder neck to electrical stimulation of the lumbar splanchnic nerve (LSN) or the HGN were examined. In six dogs whose hypogastric nerve was injured bilaterally as described a bove 4 years before, corresponding to more than 20 years in human, nine (43 %) and 13 (57 %) of the 21 LSNs stimulated elicited elevation of vasal and bladder neck pressure, respectively. By combining re-transection of a HGN, the following pathways to the vas deferens/epididymis were identified to h ave been reconstructed: (1) to the ipsilateral vas deferens/epididymis with out crossing to the other side; (2) to the contralateral vas deferens/epidi dymis by crossing to the other side at the caudal mesenteric plexus (CMP); (3) to the contralateral vas deferens/epididymis by crossing to the other s ide from the ipsilateral HGN at the commissural branches between the right and left pelvic plexuses (CBPP); and (4) to the ipsilateral vas deferens/ep ididymis by crossing twice at the CMP to the other side and at the CBPP aga in from the contralateral HGN to the ipsilateral side. The similar patterns of reconstruction were also observed in the bladder neck. The above result s indicate that the sympathetic pathways via the HGN to the canine seminal tract can be reconstructed spontaneously in a high rate over a long period after serious injuries and that their cross-innervation system can be repai red. (C) 2001 Elsevier Science B.V. All rights reserved.