Three sets of diagnostic criteria for major depression and correlations with serotonin-induced platelet calcium mobilization in cancer patients

Citation
Y. Uchitomi et al., Three sets of diagnostic criteria for major depression and correlations with serotonin-induced platelet calcium mobilization in cancer patients, PSYCHOPHAR, 153(2), 2001, pp. 244-248
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
Volume
153
Issue
2
Year of publication
2001
Pages
244 - 248
Database
ISI
SICI code
Abstract
Objective: Enhanced serotonin-induced platelet calcium mobilization has bee n proposed to be a biological marker for the pathophysiology of major depre ssion in physically healthy patients. To determine the most appropriate met hod of diagnosing major depression in cancer patients, we compared serotoni n-induced platelet calcium mobilization between patients with and without m ajor depression diagnosed according to three different sets of diagnostic c riteria (inclusive, substitutive and exclusive). Methods: Among the cancer patients referred to our institution between June 1997 and March 1998, 24 p atients diagnosed as having major depression according to the inclusive app roach (in which the nine traditional symptoms of major depression contribut e towards the diagnosis of depression regardless of its presumed etiology) participated in the study. Serotonin-induced platelet calcium mobilization was examined in these patients and in the same number of non-depressed cont rols matched for age, sex, cancer stage and cancer site. The depressed pati ents were then re-evaluated using substitutive and exclusive criteria, and calcium mobilization comparisons with the relevant controls were repeated. Results: Compared with the controls, an enhanced serotonin-induced platelet calcium response was only observed in the patients with major depression a ccording to the exclusive criteria. No significant enhancement was observed when the inclusive or substitutive approaches were used. Conclusion: These findings, based on the use of enhanced serotonin-induced platelet calcium mobilization as a biological marker, suggest that the exclusive approach mi ght be the most valid and appropriate method of diagnosing major depression in cancer patients, while the inclusive and substitutive approaches might overestimate the occurrence of major depression in these patients.