Mesityllithium as a reagent for chemoselective halogen-lithium exchange reaction

Citation
Y. Kondo et al., Mesityllithium as a reagent for chemoselective halogen-lithium exchange reaction, ORG LETT, 3(1), 2001, pp. 13-15
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
3
Issue
1
Year of publication
2001
Pages
13 - 15
Database
ISI
SICI code
1523-7060(20010111)3:1<13:MAARFC>2.0.ZU;2-U
Abstract
[GRAPHICS] Mesityllithium was found to be an excellent selective lithiating agent to p repare aryllithium compounds having alkoxycarbonyl groups. To extend our st udies on chemoselective lithiation, an important precursor for the synthesi s of camptothecin was prepared using a halogen-lithium exchange reaction fo llowed by an intramolecular 1,2-addition.