In vivo acceleration of heart relaxation performance by parvalbumin gene delivery

Citation
Ml. Szatkowski et al., In vivo acceleration of heart relaxation performance by parvalbumin gene delivery, J CLIN INV, 107(2), 2001, pp. 191-197
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
JOURNAL OF CLINICAL INVESTIGATION
ISSN journal
0021-9738 → ACNP
Volume
107
Issue
2
Year of publication
2001
Pages
191 - 197
Database
ISI
SICI code
0021-9738(200101)107:2<191:IVAOHR>2.0.ZU;2-Z
Abstract
Defective cardiac muscle relaxation plays a causal role in heart failure. S hown here is the new in vivo application of parvalbumin, a calcium-binding protein that facilitates ultrafast relaxation of specialized skeletal muscl es. Parvalbumin is not naturally expressed in the heart. We show that parva lbumin gene transfer to the heart in vivo produces levels of parvalbumin ch aracteristic of fast skeletal muscles, causes a physiologically relevant ac celeration of heart relaxation performance in normal hearts, and enhances r elaxation performance in an animal model of slowed cardiac muscle relaxatio n. Parvalbumin may offer the unique potential to correct defective relaxati on in energetically compromised failing hearts because the relaxation-enhan cement effect of parvalbumin arises from an ATP-independent mechanism. Addi tionally, parvalbumin gene transfer may provide a new therapeutic approach to correct cellular disturbances in calcium signaling pathways that cause a bnormal growth or damage in the heart or other organs.