Dipsogenic response induced by angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in rats

Citation
J. Tanaka et al., Dipsogenic response induced by angiotensinergic pathways from the lateral hypothalamic area to the subfornical organ in rats, BEH BRA RES, 118(2), 2001, pp. 111-116
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BEHAVIOURAL BRAIN RESEARCH
ISSN journal
0166-4328 → ACNP
Volume
118
Issue
2
Year of publication
2001
Pages
111 - 116
Database
ISI
SICI code
0166-4328(20010129)118:2<111:DRIBAP>2.0.ZU;2-R
Abstract
Experimental observations in several species have suggested that angiotensi nergic neural circuits from the lateral hypothalamic area (LHA) to the subf ornical organ (SFO) may participate in the control of drinking behavior in the rat. In an attempt to verify this possibility, experiments were underta ken to investigate whether activation of LHA neurons Following microinjecti on of angiotensin II (ANG II) into the LHA elicits drinking. Injections of ANC II (10(-11) mol) into the LHA caused drinking in 25 out of 36 rats havi ng the tips of cannulas in the LHA. The efficacy of ANG II was potentiated by increasing the dose of the drug. To clarify the contribution of angioten sinergic neurons in the LHA with efferent projections to the SFO to the dri nking induced by ANG II, the effects of pretreatment with saralasin (Sar), a specific ANG II antagonist, in the SFO or its surrounding region on the d rinking to ANG II were examined. Previous injections of Sar into the SFO si gnificantly reduced the water intake caused by ANG II injected into the LHA , whereas treatment with Sar in the ventral hippocampal commissure (VHC) or third ventricle (3V) was without effect. These findings provide the eviden ce for the involvement of the angiotensinergic pathways from the LHA to the SFO in the dipsogenic action. (C) 2001 Elsevier Science B.V. All rights re served.