Impaired vascular responses to nitroglycerin in subjects with coronary atherosclerosis

Authors
Raitakari, OT Seale, JP Celermajer, DS
Citation
Ot. Raitakari et al., Impaired vascular responses to nitroglycerin in subjects with coronary atherosclerosis, AM J CARD, 87(2), 2001, pp. 217
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
0002-9149 → ACNP
Volume
87
Issue
2
Year of publication
2001
Database
ISI
SICI code
0002-9149(20010115)87:2<217:IVRTNI>2.0.ZU;2-9
Abstract
To study smooth muscle function in atherosclerosis, we calculated dose-resp onse curves in patients with coronary artery disease and in controls by mea suring changes in brachial artery diameter after incremental sublingual dos es of nitroglycerin. The doses required to produce a 50% maximal dilator re sponse were significantly higher in patients with coronary artery disease t han in controls (p < 0.002), suggesting smooth muscle dysfunction in athero sclerosis.