Biobrane (R) improves wound healing in burned children without increased risk of infection

Citation
S. Lal et al., Biobrane (R) improves wound healing in burned children without increased risk of infection, SHOCK, 14(3), 2000, pp. 314-318
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Cardiovascular & Hematology Research
Journal title
SHOCK
ISSN journal
1073-2322 → ACNP
Volume
14
Issue
3
Year of publication
2000
Pages
314 - 318
Database
ISI
SICI code
1073-2322(200009)14:3<314:B(IWHI>2.0.ZU;2-B
Abstract
A synthetic bilaminar membrane used as a skin substitute (Biobrane(R)) has been shown to decrease pain and hospitalization in superficial second-degre e burns. Despite these benefits, it has not been utilized universally, part icularly in young children, due to a perceived increase in related infectio ns. We propose that when this synthetic membrane is applied to superficial scald burns <25% of the total body surface area (TBSA), decreased healing t imes are expected without increased risk of infection. Between 1994-1999, 8 9 children treated within 48 h after receiving superficial partial thicknes s scald burns covering 5-25% TBSA with no indication of infection were seen at our hospital. Forty-one were assigned randomly to receive treatment wit h the skin substitute Biobrane and 48 to receive conservative treatment wit h topical antimicrobials and dressing changes. Comparisons of treatment wer e made between groups for length of hospitalization, wound healing times, a nd infectious complications. Children treated with Biobrane or topical anti microbials were similar in age, race, sex, %TBSA burned, and location of bu rn. Those receiving Biobrane had shorter hospitalizations and healing times , which was significant for both infants and toddlers and older children. T reatment groups were not different in the use of systemic antibiotics or re admissions for infectious complications. Biobrane was removed in 5.9% of ca ses for non-adherence. The application of Biobrane within 48 h of superfici al burns provides for shorter hospitalizations and faster healing times in children of all ages without increased risk of infection.