Cerebrospinal fluid tau concentrations in HIV infected patients with suspected neurological disease

Citation
Aje. Green et al., Cerebrospinal fluid tau concentrations in HIV infected patients with suspected neurological disease, SEX TRANS I, 76(6), 2000, pp. 443-446
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease","da verificare
Journal title
SEXUALLY TRANSMITTED INFECTIONS
ISSN journal
1368-4973 → ACNP
Volume
76
Issue
6
Year of publication
2000
Pages
443 - 446
Database
ISI
SICI code
1368-4973(200012)76:6<443:CFTCIH>2.0.ZU;2-O
Abstract
Objectives: To measure cerebrospinal fluid (CSF) tau in HIV infected patien ts with acute neurological episodes and to correlate the findings with thr type and severity of neurological disease. Methods: CSF tau was prospectively measured in 76 consecutive HIV infected patients admitted to a specialist unit at UCL Hospitals, London, for invest igation of acute neurological episodes: the results were compared with the clinical diagnoses. Results: 24 patients had HIV associated dementia complex (HADC), 10 had lym phoma (including four with primary CNS lymphoma), 20 had cerebral infection s (including five with CMV encephalitis, five with VZV infection, seven wit h cryptococcal meningitis, two with toxoplasmosis, and one with progressive multifocal leucoencephalopathy); 22 patients had miscellaneous conditions, including nine with self limiting headache/fever. 62 patients (82%) had no rmal CSF tau concentration and 14 patients (18%) had elevated tau. In those with HADC, there was no correlation between the degree of dementia or atro phy on magnetic resonance imaging and CSF tau. Elevated CSF tau was associa ted with poor outcome as six of eight patients who died within 4 weeks of l umbar puncture had elevated tau (p=0.0024, two tailed Fisher's exact test). Conclusions: CSF tau levels are not elevated in the majority of HIV infecte d patients presenting with acute neurological episodes. CSF tau levels show no correlation with severity of dementia/ atrophy on magnetic resonance im aging. Although elevated CSF tau was observed in some patients with conditi ons causing cerebral necrosis, the finding did not delineate underlying pat hology but was associated with poor outcome.