Age, sex, haemoglobin level, and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treatedwith BFM-type protocol

Citation
Sm. Ng et al., Age, sex, haemoglobin level, and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treatedwith BFM-type protocol, J TROP PEDI, 46(6), 2000, pp. 338-343
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics
Journal title
JOURNAL OF TROPICAL PEDIATRICS
ISSN journal
0142-6338 → ACNP
Volume
46
Issue
6
Year of publication
2000
Pages
338 - 343
Database
ISI
SICI code
0142-6338(200012)46:6<338:ASHLAW>2.0.ZU;2-E
Abstract
The presenting features and treatment outcome for 575 Malaysian children (l ess than or equal to 12 years of age) with newly diagnosed acute lymphoblas tic leukemia (ALL), admitted to the University Hospital, Kuala Lumpur, Mala ysia between 1 January 1980 and 30 May 1995 were evaluated to determine the ir prognostic significance, Two-year overall survival was achieved in 67 pe r cent of all patients and 55 per cent of patients were relapse-free at 2 y ears. All except 10 patients, with identified French-American-British L3 mo rphology were treated with the modified Berlin-Frankfurt-Munster 78 treatme nt protocol. Univariate analyses of failure rate conferred age, sex, white cell count and hemoglobin level as potentially significant prognostic facto rs. All four presenting features retained their prognostic strength in a mu ltivariate analysis, Race, platelet count, morphological subtype, liver/spl een size, lymphadenopathy, central nervous system and mediastinal mass invo lvement did not show any significant effect on treatment outcome. The 2-yea r survival rate was significantly different with regard to age, white cell count and hemoglobin level, However, sex was not significantly related to o verall survival, These prognostic factors may have implications on future s tratification of risk-adjusted initial treatment in the management of child hood ALL, Our analysis of Malaysian children is similar to what could be pr edicted based on previous studies in other populations.