Voltammetry of platinum in artificial perilymph solution

Citation
Db. Hibbert et al., Voltammetry of platinum in artificial perilymph solution, J ELCHEM SO, 148(1), 2001, pp. E1-E7
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physical Chemistry/Chemical Physics","Material Science & Engineering
Journal title
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
ISSN journal
0013-4651 → ACNP
Volume
148
Issue
1
Year of publication
2001
Pages
E1 - E7
Database
ISI
SICI code
0013-4651(200101)148:1<E1:VOPIAP>2.0.ZU;2-Z
Abstract
Mammalian cochlea perilymph contains amino acids and protein which have a m ajor effect on the electrochemistry of an implanted auditory prosthesis. Cy clic voltammetry in an artificial perilymph solution shows that many amino acids adsorb at the platinum electrode diminishing oxidation of the metal, and also blocking hydrogen evolution. At anodic potentials > 900 mV vs. sil ver/silver chloride they are oxidized leaving adsorbed oxidation products. The sulfur-containing amino acids cysteine and methionine have the greatest effects. Protein (human serum albumen, HSA) has a similar hat smaller effe ct. A solution containing HSA (2 mg mL(-1)), phenylalanine (175 muM), glyci ne (396 muM), and proline (40 muM) in phosphate buffered saline is proposed as a suitable artificial perilymph solution having similar electrochemical and adsorption properties to perilymph. (C) 2000 The Electrochemical Socie ty. S0013-4651(99)12-019-4. All rights reserved.