Vitamin D receptor gene polymorphism is associated with serum total and ionized calcium concentration

Citation
Y. Nakano et al., Vitamin D receptor gene polymorphism is associated with serum total and ionized calcium concentration, J MOL MED-J, 78(10), 2000, pp. 575-579
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
JOURNAL OF MOLECULAR MEDICINE-JMM
ISSN journal
0946-2716 → ACNP
Volume
78
Issue
10
Year of publication
2000
Pages
575 - 579
Database
ISI
SICI code
0946-2716(2000)78:10<575:VDRGPI>2.0.ZU;2-Y
Abstract
Restriction fragment length polymorphisms of the vitamin D receptor gene ha ve recently been reported to be associated with changes in bone mineral den sity. Alterations in systemic calcium balance and Ca-regulating hormones su ch as 1,25(OH)(2) vitamin D-3 and parathyroid hormone have been demonstrate d in essential hypertension. We investigated the relationship between polym orphisms of the vitamin D receptor gene and systemic Ca metabolism in patie nts with essential hypertension and in normotensives. We compared 147 subje cts with essential hypertension and 100 normotensive control subjects. The genotype distribution and derived allele frequencies for the vitamin D rece ptor gene were similar in the two groups (genotype bb/Bb/BB and allele B/b: 60.1/32.6/7.2 and 0.24/0.76 in hypertensives vs. 56.0/36.0/8.0 and 0.26/0. 74 in normotensive subjects). Serum concentrations of total Ca in the bb, B b, and BB groups were, respectively, 4.5+/-0.3 vs. 4.5+/-0.4 vs. 4.4+/- 0.5 mmol/l in normotensives and 4.6+/-0.3 vs. 4.6+/-0.4 vs. 4.4+/-0.5 mmol/l i n hypertensives. Ionized Ca levels were 1.17+/-0.04 vs. 1.16+/-0.04 vs. 1.1 5+/-0.04 mmol/l in normotensives and 1.16+/-0.04 vs. 1.16+/-0.04 vs. 1.14+/ -0.05 mmol/l in hypertensives, respectively. These results indicate that th e BB genotype of the vitamin D receptor gene is associated with lower serum Ca levels but is not a useful predictive marker for the development of ess ential hypertension in Japanese subjects.