Y. Nakano et al., Vitamin D receptor gene polymorphism is associated with serum total and ionized calcium concentration, J MOL MED-J, 78(10), 2000, pp. 575-579
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Restriction fragment length polymorphisms of the vitamin D receptor gene ha
ve recently been reported to be associated with changes in bone mineral den
sity. Alterations in systemic calcium balance and Ca-regulating hormones su
ch as 1,25(OH)(2) vitamin D-3 and parathyroid hormone have been demonstrate
d in essential hypertension. We investigated the relationship between polym
orphisms of the vitamin D receptor gene and systemic Ca metabolism in patie
nts with essential hypertension and in normotensives. We compared 147 subje
cts with essential hypertension and 100 normotensive control subjects. The
genotype distribution and derived allele frequencies for the vitamin D rece
ptor gene were similar in the two groups (genotype bb/Bb/BB and allele B/b:
60.1/32.6/7.2 and 0.24/0.76 in hypertensives vs. 56.0/36.0/8.0 and 0.26/0.
74 in normotensive subjects). Serum concentrations of total Ca in the bb, B
b, and BB groups were, respectively, 4.5+/-0.3 vs. 4.5+/-0.4 vs. 4.4+/- 0.5
mmol/l in normotensives and 4.6+/-0.3 vs. 4.6+/-0.4 vs. 4.4+/-0.5 mmol/l i
n hypertensives. Ionized Ca levels were 1.17+/-0.04 vs. 1.16+/-0.04 vs. 1.1
5+/-0.04 mmol/l in normotensives and 1.16+/-0.04 vs. 1.16+/-0.04 vs. 1.14+/
-0.05 mmol/l in hypertensives, respectively. These results indicate that th
e BB genotype of the vitamin D receptor gene is associated with lower serum
Ca levels but is not a useful predictive marker for the development of ess
ential hypertension in Japanese subjects.