Human studies to substantiate health effects of antioxidants. What is needed?

Citation
P. Van'T Veer et Fj. Kok, Human studies to substantiate health effects of antioxidants. What is needed?, FREE RAD RE, 33, 2000, pp. S109-S115
Citations number
4
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FREE RADICAL RESEARCH
ISSN journal
1071-5762 → ACNP
Volume
33
Year of publication
2000
Supplement
S
Pages
S109 - S115
Database
ISI
SICI code
1071-5762(2000)33:<S109:HSTSHE>2.0.ZU;2-#
Abstract
Biomarkers fulfil a crucial role in studying disease etiology, both with re spect to biological plausibility, laboratory methodology, and in human stud ies. Markers should preferably reflect the mainstream causal process releva nt to a major proportion of disease. Such markers may provide the evidence required to justify health claims regarding the role of antioxidants in the etiology of chronic diseases, e.g., cancer, cardiovascular disease and cat aract. Regarding study design, type A claims, addressing enhanced biologica l function, would at least require human intervention studies. Type B claim s, addressing reduced disease risk, would require prospective data, if poss ible experimental. (Nested) case control studies may be used to establish t he predictive validity of precursor lesions of disease that can serve to su bstitute studies assessing disease occurrence as endpoints. Scientifically sound and practically feasible requirements for justification of health cla ims need be developed further.