High maternal fever during gestation and severe congenital limb disruptions

Citation
Ml. Martinez-frias et al., High maternal fever during gestation and severe congenital limb disruptions, AM J MED G, 98(2), 2001, pp. 201-203
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF MEDICAL GENETICS
ISSN journal
0148-7299 → ACNP
Volume
98
Issue
2
Year of publication
2001
Pages
201 - 203
Database
ISI
SICI code
0148-7299(20010115)98:2<201:HMFDGA>2.0.ZU;2-O
Abstract
Hyperthermia is defined as a temperature of at least 1.5 degreesC over the normal core body temperature. It is a proven teratogen in animals and in hu mans. The type of defects induced by hyperthermia in experimental animals a re: anencephaly/exencephaly, encephalocele, microphthalmia, arthrogryposis, abdominal wall defects, limb deficiencies, embryonic death, and resorption . In humans it has been observed that infants prenatally exposed to hyperth ermia presented with spins bifida, encephalocele, microphthalmia, micrognat hia, external ear anomalies, cardiac defects, hypospadias, gastrointestinal defects, cleft lip and/or cleft palate, abdominal wall defects, diaphragma tic hernia, Hirschsprung disease, Mobius syndrome, oromandibular-limb hypog enesis spectrum, and spontaneous abortions. We describe an additional case with severe limb deficiencies whose mother had fever over 39 degreesC for 2 days in the second and in the fourth month of amenorrhoea. We conclude tha t, based on the degree of development of the humeri and the femora and the type of limb deficiencies, this case presents a disruption that most probab ly occurred in the fourth month of gestation. (C) 2001 Wiley-Liss, Inc.