Pyrrolidine PNA: A novel conformationally restricted PNA analogue

Citation
A. Puschl et al., Pyrrolidine PNA: A novel conformationally restricted PNA analogue, ORG LETT, 2(26), 2000, pp. 4161-4163
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
2
Issue
26
Year of publication
2000
Pages
4161 - 4163
Database
ISI
SICI code
1523-7060(200012)2:26<4161:PPANCR>2.0.ZU;2-V
Abstract
[GRAPHICS] A new conformationally restricted RNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligon ucleotides as compared to that of the parent RNA adenine decamer.