Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes

Citation
Plr. Harris et al., Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes, NEUROBIOL A, 21(6), 2000, pp. 837-841
Citations number
47
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROBIOLOGY OF AGING
ISSN journal
0197-4580 → ACNP
Volume
21
Issue
6
Year of publication
2000
Pages
837 - 841
Database
ISI
SICI code
0197-4580(200011/12)21:6<837:NPKIAD>2.0.ZU;2-R
Abstract
Neurons of adults apparently lack the components necessary to complete the cell division process. Therefore. in Alzheimer disease. the increased expre ssion of cell cycle-related proteins in degenerating neurons likely leads t o an interrupted mitotic process associated with cytoskeletal abnormalities and, ultimately, neuronal degeneration. In this study, to further delineat e the role of mitotic processes in the pathogenesis of Alzheimer disease, w e undertook a study of polo-like kinase (Plk), a protein that plays a cruci al role in the cell cycle. Our results show disease-related increases in Pl k in susceptible hippocampal and cortical neurons in comparison to young or age-matched controls. An increase in neuronal Plk further implicates aberr ations in cell cycle control in the pathogenesis of Alzheimer disease and p rovides a novel mechanistic basis for therapeutic intervention. (C) 2000 El sevier Science Inc. All rights reserved.