OPEC/OJEC for stage 4 neuroblastoma in children over 1 year of age

Citation
Da. Tweddle et al., OPEC/OJEC for stage 4 neuroblastoma in children over 1 year of age, MED PED ONC, 36(1), 2001, pp. 239-242
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics
Journal title
MEDICAL AND PEDIATRIC ONCOLOGY
ISSN journal
0098-1532 → ACNP
Volume
36
Issue
1
Year of publication
2001
Pages
239 - 242
Database
ISI
SICI code
0098-1532(200101)36:1<239:OFS4NI>2.0.ZU;2-5
Abstract
Background. This paper reports the toxicity of OPEC/OJEC chemotherapy in st age 4 neuroblastoma patients over 1 year of age. Procedure. Ninety-five pat ients with stage 4 neuroblastoma received alternating courses of OPEC/ OJEC -vincristine 1.5 mg/m(2) (O), cisplatin 80 mg/m(2) (P), etoposide 200 mg/m( 2) (E), cyclophosphamide 600 mg/m(2) (C), and carboplatin 500 mg/m(2) U), e very 21 days if there was haematological recovery. Results. Seventy out of ninety-five (74%) patients completed seven or more courses and were evaluab le for toxicity. Of these 70 patients, 33% had more than three episodes of fever and sepsis, 35% required more than five blood or platelet transfusion s, 36% had grade 2 or more gastrointestinal toxicity and 9% had neurotoxici ty. There was a median reduction in GFR of 32 ml/min/1.73 m(2) (-46 to 134) and there was one toxic death. Conclusions. OPEC/OJEC is a well-tolerated therapy for stage 4 neuroblastoma over 1 year of age. Med. Pediatr. Oncol. 36:239-242, 2001. (C) 2001 Wiley-Liss, Inc.