Background. This paper reports the toxicity of OPEC/OJEC chemotherapy in st
age 4 neuroblastoma patients over 1 year of age. Procedure. Ninety-five pat
ients with stage 4 neuroblastoma received alternating courses of OPEC/ OJEC
-vincristine 1.5 mg/m(2) (O), cisplatin 80 mg/m(2) (P), etoposide 200 mg/m(
2) (E), cyclophosphamide 600 mg/m(2) (C), and carboplatin 500 mg/m(2) U), e
very 21 days if there was haematological recovery. Results. Seventy out of
ninety-five (74%) patients completed seven or more courses and were evaluab
le for toxicity. Of these 70 patients, 33% had more than three episodes of
fever and sepsis, 35% required more than five blood or platelet transfusion
s, 36% had grade 2 or more gastrointestinal toxicity and 9% had neurotoxici
ty. There was a median reduction in GFR of 32 ml/min/1.73 m(2) (-46 to 134)
and there was one toxic death. Conclusions. OPEC/OJEC is a well-tolerated
therapy for stage 4 neuroblastoma over 1 year of age. Med. Pediatr. Oncol.
36:239-242, 2001. (C) 2001 Wiley-Liss, Inc.