Anti-HIV agents 45 and antitumor agents 205. Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneriafloridana

Citation
Zh. Xu et al., Anti-HIV agents 45 and antitumor agents 205. Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneriafloridana, J NAT PROD, 63(12), 2000, pp. 1712-1715
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
63
Issue
12
Year of publication
2000
Pages
1712 - 1715
Database
ISI
SICI code
0163-3864(200012)63:12<1712:AA4AAA>2.0.ZU;2-P
Abstract
Two new sesquiterpenes, leitneridanin A (1) and leitneridanin B (2), and se ven known compounds, lirioresinol B, (-)-pinoresinal, (+)-lariciresinol, qu assimarin (3), simalikalactone D (4), 1-methoxycanthinone (5), and 5-methox ycanthinone (6), were isolated from Leitneria floridana. Their structures w ere identified on the basis of spectral data. In vitro biological evaluatio n showed that 5 is a potent anti-HIV agent (EC50 0.26 mug/mL; TI > 39) and that 3-6 suppressed the growth of a panel of human tumor cell lines (KB, A- 549, HCT-8, CAKI-1, MCF-7, and SK-MEL-2). Compounds 3 and 4 were significan tly active, with ED50 values in the range of 0.26-0.012 mug/mL.