Efficacy of IFN therapy based on duration period of negative HCV-RNA during IFN administration

Citation
Y. Arase et al., Efficacy of IFN therapy based on duration period of negative HCV-RNA during IFN administration, HEPATOL RES, 19(1), 2001, pp. 22-30
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
HEPATOLOGY RESEARCH
ISSN journal
1386-6346 → ACNP
Volume
19
Issue
1
Year of publication
2001
Pages
22 - 30
Database
ISI
SICI code
1386-6346(200101)19:1<22:EOITBO>2.0.ZU;2-2
Abstract
We assessed the relationship between the duration period of negative hepati tis C virus (HCV)-RNA during interferon (IFN) therapy and the efficacy afte r prolonged IFN therapy in patients with HCV-genotype Ib and high virus loa d of more than 1 mega equivalents/ml (Meq/ml) retrospectively. A total of 1 00 patients who had HCV-genotype Ib and a high virus load of more than 1 Me q/ml and were treated with natural IFN-alpha for more than 1? months were e nrolled in this trial. These patients were given 6 MU of IFN daily for 8 we eks, followed by three times weekly for another more than 44 weeks. The HCV -RNA pattern during IFN therapy according to negative or positive of the se rum HCV-RNA by reverse transcription nested polymerase chain reaction (RT-n ested PCR) from 2 months after the initiation of IFN to the termination of IFN were classified as follows: group 1: constant negative HCV-RNA (n = 41 cases), group 2. constant positive MCV-RNA (n = 35 cases), group 3: HCV-RNA pattern except for group 1 or group 2 (il = 24 cases). A complete response (CR) was defined as negative HCV-RNA by RT-nested PCR at two points, 3 and 6 months after the completion of IFN therapy. CR rate was 58.5% (24 cases) in group 1, but CR rate in group 2 or group 3 was 0%. In group 1, the CR r ate was 100%(10/10) in patients with negative HCV-RNA constantly for period of more than 24 months during IFN therapy. On the other. hand, all patient s who had positive HCV-RNA 2 months after the initiation of IFN did not get CR. In conclusion, it seems to us that the attainment of constantly negati ve I-ICV-RNA for the period of more than 24 months during IFN therapy is hi ghly related to CR. (C) 2001 Elsevier Science Ireland Ltd. All rights reser ved.