Phosphoglyceride crystal deposition disease

Citation
K. Miura et al., Phosphoglyceride crystal deposition disease, PATHOL INT, 50(12), 2000, pp. 992-998
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
PATHOLOGY INTERNATIONAL
ISSN journal
1320-5463 → ACNP
Volume
50
Issue
12
Year of publication
2000
Pages
992 - 998
Database
ISI
SICI code
1320-5463(200012)50:12<992:PCDD>2.0.ZU;2-Y
Abstract
An extremely rare phosphoglyceride deposition disease is reported. A health y 62-year-old Japanese woman suffered from tumors that repeatedly appeared in injured soft tissues for more than 20 years. No immunologic disorders or abnormal laboratory data were found. Histology showed foreign body granulo mas consisting of macrophages surrounding yellowish-white crystals. The cry stals were weakly positive by von Kossa's method, were dissolved in 30% ace tic acid with gas, and were easily dissolved in 0.1 N NaOH or potassium hyd roxide, losing their crystal structure. Using a scanning electron microscop y X-ray microanalyzer, phosphorus and calcium peaks were detected. Phosphog lycerides were detected by microscopic infrared spectrophotometry and micro sampling mass spectrometry. The gold hydroxamic acid method for detecting p hosphoglyceride showed strong positive staining in the crystals. Based on t he above analyses, the deposited crystals were regarded as phosphoglyceride , which bound calcium as a counter ion. The crystals tended to be deposited at sites of injury, where macrophages had accumulated. The patient had rec eived many injections of a medicine made from alcohol extract from bovine l iver. We suspect that this medicine was related to the cause of the deposit ion as the deposition repeatedly appeared at the site of the injections.