Study on free radicals and pancreatic fibrosis - Pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor

Citation
N. Matsumura et al., Study on free radicals and pancreatic fibrosis - Pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor, PANCREAS, 22(1), 2001, pp. 53-57
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
PANCREAS
ISSN journal
0885-3177 → ACNP
Volume
22
Issue
1
Year of publication
2001
Pages
53 - 57
Database
ISI
SICI code
0885-3177(200101)22:1<53:SOFRAP>2.0.ZU;2-7
Abstract
The exact mechanisms of the development of pancreatic fibrosis are still un known. To clarify the relationship between pancreatic fibrosis and free rad icals, the effect of the administration of a superoxide dismutase (SOD) inh ibitor, diethyldithiocarbamate (DDC), on pancreatic fibrosis in rats was st udied. A single intraperitoneal injection of 500 mg/kg of DDC significantly reduced SOD activity and significantly increased lipid peroxidation produc ts in the pancreas, showing no histologic changes of inflammation or necros is. Repeated administration of 500 mg/kg DDC, twice a week, caused inter- a nd intralobular fibrosis with atrophy of acinar cells in the pancreas for a t least 2 weeks without fibrosis of the liver and kidney. Administration of allopurinol showed preventive effects against DDC-induced pancreatic fibro sis. In conclusion, repeated administration of DDC, which caused pancreatic fibrosis, is a new experimental model of pancreatic fibrosis from the view point of oxidative stress.