Study on free radicals and pancreatic fibrosis - Pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor

Matsumura, N Ochi, K Ichimura, M Mizushima, T Harada, H Harada, M

N. Matsumura et al., Study on free radicals and pancreatic fibrosis - Pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor, PANCREAS, 22(1), 2001, pp. 53-57

16

INGLESE

Article

da verificare

PANCREAS

0885-3177 → ACNP

22

1

2001

53 - 57

ISI

0885-3177(200101)22:1<53:SOFRAP>2.0.ZU;2-7

The exact mechanisms of the development of pancreatic fibrosis are still un known. To clarify the relationship between pancreatic fibrosis and free rad icals, the effect of the administration of a superoxide dismutase (SOD) inh ibitor, diethyldithiocarbamate (DDC), on pancreatic fibrosis in rats was st udied. A single intraperitoneal injection of 500 mg/kg of DDC significantly reduced SOD activity and significantly increased lipid peroxidation produc ts in the pancreas, showing no histologic changes of inflammation or necros is. Repeated administration of 500 mg/kg DDC, twice a week, caused inter- a nd intralobular fibrosis with atrophy of acinar cells in the pancreas for a t least 2 weeks without fibrosis of the liver and kidney. Administration of allopurinol showed preventive effects against DDC-induced pancreatic fibro sis. In conclusion, repeated administration of DDC, which caused pancreatic fibrosis, is a new experimental model of pancreatic fibrosis from the view point of oxidative stress.