Lack of evidence to support the association of the human prion gene with schizophrenia

Citation
Mt. Tsai et al., Lack of evidence to support the association of the human prion gene with schizophrenia, MOL PSYCHI, 6(1), 2001, pp. 74-78
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR PSYCHIATRY
ISSN journal
1359-4184 → ACNP
Volume
6
Issue
1
Year of publication
2001
Pages
74 - 78
Database
ISI
SICI code
1359-4184(200101)6:1<74:LOETST>2.0.ZU;2-M
Abstract
Recently a new Variant of Creutzfeldt-Jakob disease, a human prion disease, with prominent psychiatric manifestations in the early stage was identifie d, suggesting that human prion disease may be associated with mental disord ers. Furthermore, a novel missense mutation with asparagine-to-serine subst itution at codon 171 of the human prion gene (N171S) was identified in a fa mily with severe psychiatric symptoms. This finding provides further clue t hat the prion gene may be a susceptibility gene for certain psychiatric dis orders. We systematically sequenced the protein-coding and untranslated exo ns of prion gene in 62 Han Chinese schizophrenic patients with positive fam ily history from Taiwan. We identified two polymorphisms that alter amino a cid sequences, a methionine/valine at codon 129 (M129V) and a glutamate/lys ine at codon 219 (E219K), respectively. Further comparison of the genotype, allele and haplotype frequency distributions of these two polymorphisms be tween 234 schizophrenic patients and 100 non-psychotic controls, however, d id not reveal significant differences between two groups. Besides, no other mutations in the prion gene were identified in these 62 patients. Hence, o ur results suggest that the prion gene may not play a major role in conferr ing susceptibility to schizophrenia.