Two- and three-dimensional assessments of myocardial perfusion and function by using technetium-99m sestamibi gated SPECT with a combination of count- and image-based techniques

Citation
T. Nakata et al., Two- and three-dimensional assessments of myocardial perfusion and function by using technetium-99m sestamibi gated SPECT with a combination of count- and image-based techniques, J NUCL CARD, 7(6), 2000, pp. 623-632
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF NUCLEAR CARDIOLOGY
ISSN journal
1071-3581 → ACNP
Volume
7
Issue
6
Year of publication
2000
Pages
623 - 632
Database
ISI
SICI code
1071-3581(200011/12)7:6<623:TATAOM>2.0.ZU;2-U
Abstract
Background. Although the myocardial gated single photon emission computed t omography (SPECT) technique makes it possible to assess concurrent myocardi al perfusion and function, quantitative methods for analyzing and displayin g gated SPECT data in 2- and 3-dimensional presentations for regional and g lobal cardiac assessment have not been established. Methods and Results, We have developed an automated quantitative method for assessing perfusion and function by means of technetium-99m sestamibi gate d SPECT with a computerized technique combining count-based and image-based methods. We have examined its validity in 91 patients by comparing its res ults with those of conventional techniques: contrast left ventriculography and radionuclide angiocardiography, In addition to color-scale displays of regional function, simultaneous 3-dimensional presentations of regional wal l motion and perfusion have been produced. High reproducibility of gated SP ECT analysis with this algorithm was demonstrated; interoperator errors (%C V) were 2.6% to 5.5%, and good intraobserver reproducibility was confirmed by means of high correlation coefficients (0.954 to 0.989), Left ventricula r volumes assessed by means of contrast left ventriculography and by means of the gated SPECT technique showed significant correlations (left ventricu lar end-diastolic volume, y = 1.01x - 9.7, r = 0.845, P <.001, standard err ors of the estimate [SEE] = 14 mL; left ventricular end-systolic volume, y = 1.03x - 1.4, r = 0.902, P <.001, SEE = 6 mL). Left ventricular ejection f raction determined by means of gated SPECT with the new algorithm closely c orrelated with that determined by means of radionuclide ventriculography (y = 1.05x - 0.6, r = 0.891, P <.001, SEE = 3%). These parameters quantified by means of the present method correlated closely with those derived from t he QGS program (r = 0.926 to 0.987). Conclusion. In comparison with conventional techniques, myocardial gated SP ECT with automated quantitative analysis provides accurate and reproducible data for global and regional function. Quantitative concurrent assessment of myocardial perfusion and function by using 2- and 3-dimensional represen tations appears to be superior to other modalities and to contribute to nuc lear cardiology practice.