Novel membrane materials having EEE derivatives as a chiral recognition site

Yoshikawa, M Ooi, T Izumi, J

M. Yoshikawa et al., Novel membrane materials having EEE derivatives as a chiral recognition site, EUR POLYM J, 37(2), 2001, pp. 335-342

18

INGLESE

Article

Organic Chemistry/Polymer Science

EUROPEAN POLYMER JOURNAL

0014-3057 → ACNP

37

2

2001

335 - 342

ISI

0014-3057(200102)37:2<335:NMMHED>2.0.ZU;2-J

Molecularly imprinted polymeric membranes with tripeptide residue H-Glu(OBz l)-Glu(OBzl)-Glu(OBzl)-CH2-(EEE) were prepared during the membrane preparat ion process in the presence of a print molecule. The Boc-L-Trp imprinted po lymeric membranes thus obtained showed adsorption selectivity toward the pr int molecule analogue, Acr-Trp. From the adsorption isotherms of Ac-Trp's, the chiral recognition site, which was formed by the print molecule in the membrane preparation process, exclusively recognizes Ac-L-Trp, and the oppo site isomer, Ac-D-Trp, is rejected. Enantioselective electrodialysis was at tained and the separation factor toward L-isomer reached 5.0, reflecting ad sorption selectivity. The membrane performance, such as the amount of enant iomer recognized and flux value of enantioselective electrodialysis, are gr eatly dependent on the concentration of tripeptide residues in the membrane . (C) 2000 Elsevier Science Ltd. All rights reserved.