The C-elegans F-box/WD-repeat protein LIN-23 functions to limit cell division during development

Citation
Et. Kipreos et al., The C-elegans F-box/WD-repeat protein LIN-23 functions to limit cell division during development, DEVELOPMENT, 127(23), 2000, pp. 5071-5082
Citations number
60
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
DEVELOPMENT
ISSN journal
0950-1991 → ACNP
Volume
127
Issue
23
Year of publication
2000
Pages
5071 - 5082
Database
ISI
SICI code
0950-1991(200012)127:23<5071:TCFPLF>2.0.ZU;2-3
Abstract
In multicellular eukaryotes, a complex program of developmental signals reg ulates cell growth and division by controlling the synthesis, activation an d degradation of G(1) cell cycle regulators. Here we describe the lin-23 ge ne of Caenorhabditis elegans, which is required to restrain cell proliferat ion in response to developmental cues. In lin-23 null mutants, all postembr yonic blast cells undergo extra divisions, creating supernumerary cells tha t can differentiate and function normally. In contrast to the inability to regulate the extent of blast cell division in lin-23 mutants, the timing of initial cell cycle entry of blast cells is not affected, lin-23 encodes an F-box/WD-repeat protein that is orthologous to the Saccharomyces cerevisia e gene MET30, the Drosophila melanogaster gene slmb and the human gene beta TRCP, all of which function as components of SCF ubiquitin-ligase complexe s. Lass of function of the Drosophila slmb gene causes the growth of ectopi c appendages in a non-cell autonomous manner, In contrast, lin-23 functions cell autonomously to negatively regulate cell cycle progression, thereby a llowing cell cycle exit in response to developmental signals.