T-gamma gene rearrangement and CMV mononucleosis

Citation
P. Mathew et al., T-gamma gene rearrangement and CMV mononucleosis, AM J HEMAT, 66(1), 2001, pp. 64-66
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
0361-8609 → ACNP
Volume
66
Issue
1
Year of publication
2001
Pages
64 - 66
Database
ISI
SICI code
0361-8609(200101)66:1<64:TGRACM>2.0.ZU;2-F
Abstract
A clonal T-gamma rearrangement was found in peripheral blood and bone marro w in a 57-year-old female who presented with 6-week history of fevers, nigh t sweats, and weight loss. Splenomegaly, hemolytic anemia, atypical lymphoc ytosis, a marrow lymphoid aggregate, and elevated LDH had suggested lymphop roliferative disease. However, IgM serology for cytomegalovirus (CMV) was p ositive. With observation alone, her clinical features improved over 4 week s with normalization of the blood count and disappearance of CMV viremia an d the aberrant T-gamma clone. Acute CMV infection may mimic lymphoprolifera tive disease. T-gamma gene rearrangement may be part of the immune response to CMV infection and is not specific to lymphoid neoplasia. (C) 2001 Wiley -Liss, Inc.