CD20-positive adult T-cell leukemia

Authors
Yasukawa, M Arai, J Kakimoto, M Sakai, I Kohno, H Fujita, S
Citation
M. Yasukawa et al., CD20-positive adult T-cell leukemia, AM J HEMAT, 66(1), 2001, pp. 39-41
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF HEMATOLOGY
ISSN journal
0361-8609 → ACNP
Volume
66
Issue
1
Year of publication
2001
Pages
39 - 41
Database
ISI
SICI code
0361-8609(200101)66:1<39:CATL>2.0.ZU;2-N
Abstract
A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detec ted, and a diagnosis of adult T-cell leukemia (ATL) was made, Flow cytometr y revealed that the ATL cells expressed CD20 as well as T-cell-associated a ntigens, and expression of CD20 mRNA was also demonstrated. A novel T-cell subpopulation expressing CD20 molecules has recently been identified. This is the first report of CD20-positive ATL, suggesting that HTLV-I can infect and transform CD20-positive T cells. (C) 2001 Wiley-Liss, Inc.