A 67-year-old woman was admitted to our hospital because of lymphadenopathy
and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detec
ted, and a diagnosis of adult T-cell leukemia (ATL) was made, Flow cytometr
y revealed that the ATL cells expressed CD20 as well as T-cell-associated a
ntigens, and expression of CD20 mRNA was also demonstrated. A novel T-cell
subpopulation expressing CD20 molecules has recently been identified. This
is the first report of CD20-positive ATL, suggesting that HTLV-I can infect
and transform CD20-positive T cells. (C) 2001 Wiley-Liss, Inc.