Mechanisms of hyponatraemia in alcohol patients

Citation
Gl. Liamis et al., Mechanisms of hyponatraemia in alcohol patients, ALC ALCOHOL, 35(6), 2000, pp. 612-616
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ALCOHOL AND ALCOHOLISM
ISSN journal
0735-0414 → ACNP
Volume
35
Issue
6
Year of publication
2000
Pages
612 - 616
Database
ISI
SICI code
0735-0414(200011/12)35:6<612:MOHIAP>2.0.ZU;2-K
Abstract
Hyponatraemia is commonly reported in chronic alcoholic patients. However, the underlying pathogenetic mechanisms are not well delineated. In the curr ent study, we analysed the possible pathophysiological mechanisms of hypona traemia in a group of alcoholic patients (n = 127) admitted to our hospital for causes related to alcohol misuse. Hyponatraemia (serum sodium <134 mmo l/l) was found in 22 patients (17.3%). The most common cause of hyponatraem ia in our cohort was hypovolaemia (12 patients); pseudohyponatraemia was di agnosed in six patients with alcohol-induced severe hypertriglyceridaemia. It is of interest that two patients fulfilled the criteria of the so-called 'beer potomania' syndrome, while in two others, hyponatraemia was due to r eset osmostat or to cerebral salt wasting syndrome, not previously describe d in alcoholic patients. It is concluded that hyponatraemia is a frequently observed electrolyte disorder in hospitalized alcoholic patients and is re lated to various pathophysiological mechanisms.