Effects of ethanol on extracellular amino acid levels in high- and low-alcohol sensitive rats: A microdialysis study

Citation
A. Dahchour et al., Effects of ethanol on extracellular amino acid levels in high- and low-alcohol sensitive rats: A microdialysis study, ALC ALCOHOL, 35(6), 2000, pp. 548-553
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ALCOHOL AND ALCOHOLISM
ISSN journal
0735-0414 → ACNP
Volume
35
Issue
6
Year of publication
2000
Pages
548 - 553
Database
ISI
SICI code
0735-0414(200011/12)35:6<548:EOEOEA>2.0.ZU;2-3
Abstract
Selectively bred high-alcohol sensitive (HAS) and low-alcohol sensitive (LA S) rats possess a number of behavioural and electrophysiological difference s in their responses to alcohol. Using a microdialysis technique, we have e valuated whether the levels of the amino acids aspartate, glutamate, argini ne, taurine, and alanine in HAS and LAS rats differ in their response to et hanol administration (2 g/kg, i.p.). The basal concentrations of each amino acid in these two groups were statistically similar. Following ethanol inj ection, alanine, arginine, and glutamate were significantly decreased in HA S rats, whereas, alanine, glutamate, and taurine were significantly increas ed in LAS rats by the end of the experiment. Interestingly, an increase in the sulphonated amino acid taurine was only evident 20 min after ethanol ad ministration in the HAS rats, when compared to saline controls. No changes were observed in the other amino acids studied, aspartate and glycine, afte r ethanol administration. These data suggest that, in addition to different ial behavioural responses to alcohol, HAS and LAS rats also differ in their neurochemical responses to ethanol.