Facile and efficient total synthesis of (+)-Preussin

Citation
Ky. Lee et al., Facile and efficient total synthesis of (+)-Preussin, ORG LETT, 2(25), 2000, pp. 4041-4042
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
2
Issue
25
Year of publication
2000
Pages
4041 - 4042
Database
ISI
SICI code
1523-7060(200012)2:25<4041:FAETSO>2.0.ZU;2-U
Abstract
The enantioselective total synthesis of (+)-preussin, a potent antifungal a gent, has been achieved, The key steps are a Pd(0)-catalyzed oxazoline form ing reaction from L-phenylalanine, hydrogenolysis, and subsequent diastereo selective reductive cyclization of the intermediate aminoketone to pyrrolid ine using Pearlman's catalyst.