Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer

Citation
T. Ubagai et al., Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer, ONCOL REP, 8(1), 2001, pp. 83-88
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021-335X → ACNP
Volume
8
Issue
1
Year of publication
2001
Pages
83 - 88
Database
ISI
SICI code
1021-335X(200101/02)8:1<83:CGHASA>2.0.ZU;2-1
Abstract
We analyzed the chromosomal gains and losses that occur in 30 non-small cel l lung carcinomas by comparative genomic hybridization. Their chromosomal i mbalances showed histological type-specific patterns in adenocarcinomas and in squamous cell carcinomas. The genetic changes in non-small cell lung ca rcinoma were also strongly dependent on metastasis to lymph node. The avera ge numbers of chromosomal alterations were increased from 6.2 to 9.1 along with the presence of metastasis, and it gave rise to the increased copy num ber in specific chromosomes. In particular, a novel imbalance at 7p12-21 wa s recognized in a half of carcinoma with metastasis, although no genetic al teration was observed in 15 non-metastasizing lung carcinoma tested here.