Noradrenaline concentrations in human preovulatory follicular fluid exceedthose in peripheral plasma

Citation
Mt. Itoh et al., Noradrenaline concentrations in human preovulatory follicular fluid exceedthose in peripheral plasma, EXP CL E D, 108(8), 2000, pp. 506-509
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
ISSN journal
0947-7349 → ACNP
Volume
108
Issue
8
Year of publication
2000
Pages
506 - 509
Database
ISI
SICI code
0947-7349(2000)108:8<506:NCIHPF>2.0.ZU;2-J
Abstract
The concentrations of noradrenaline in preovulatory follicular fluid obtain ed from women undergoing in vitro fertilization were determined by high-per formance liquid chromatography with fluorometric detection and compared wit h those in peripheral plasma obtained concurrently. All of the follicular f luid samples contained noradrenaline at concentrations substantially higher than those in the corresponding plasma samples. A positive correlation was found between noradrenaline levels in follicular fluid and plasma in each woman (n=11; r=0.952; p<0.001). However, there was no significant differenc e between noradrenaline concentrations in follicular fluid aspirated from f ollicles with or without an oocyte [mean+/-SEM, 0.207 +/- 0.002 ng/<mu>l fo r follicular fluid samples with an oocyte (n=44), and 0.221 +/- 0.003 ng/mu l for follicular fluid samples without an oocyte (n=13)]. The data indicate that noradrenaline accumulates in follicular fluid, supporting the physiol ogical significance of noradrenaline in the local regulation of human ovari an functions.