Longitudinal elongation of primary afferent axons in the dorsal funiculus of the chick embryo spinal cord

Citation
T. Shiga et al., Longitudinal elongation of primary afferent axons in the dorsal funiculus of the chick embryo spinal cord, DEV BRAIN R, 124(1-2), 2000, pp. 25-31
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
DEVELOPMENTAL BRAIN RESEARCH
ISSN journal
0165-3806 → ACNP
Volume
124
Issue
1-2
Year of publication
2000
Pages
25 - 31
Database
ISI
SICI code
0165-3806(20001130)124:1-2<25:LEOPAA>2.0.ZU;2-Q
Abstract
The longitudinal elongation of primary afferent axons (PAAs) in the dorsal funiculus of chick embryo spinal cord was examined using a lipophilic trace r, DiI and immunohistochemistry. The earliest developing PAAs in the brachi al segments invaded the spinal cord around embryonic day (E) 3.5. Thereafte r, they elongated both rostrally and caudally in the presumptive dorsal fun iculus, with frequent contacts between pre-existing axons and later arrivin g growth cones. By E3, the PAAs had elongated 3 segments both rostrally and caudally. In the course of their longitudinal elongation, the PAAs shifted their trajectory dorsally within the dorsal funiculus. By E6-6.5, the PAAs had extended as far as 10 segments rostrally and 6 segments caudally in th e dorsal funiculus, and collaterals began to enter the dorsal horn. By E9, the PAAs extended up to 13 segments rostrally and 7 segments caudally, and collaterals reached the ventral spinal cord. During their longitudinal cour se, the PAAs shifted their trajectory medially within the dorsal funiculus. (C) 2000 Elsevier Science B.V. All rights reserved.