EphB receptors interact with NMDA receptors and regulate excitatory synapse formation

Citation
Mb. Dalva et al., EphB receptors interact with NMDA receptors and regulate excitatory synapse formation, CELL, 103(6), 2000, pp. 945-956
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL
ISSN journal
0092-8674 → ACNP
Volume
103
Issue
6
Year of publication
2000
Pages
945 - 956
Database
ISI
SICI code
0092-8674(200012)103:6<945:ERIWNR>2.0.ZU;2-3
Abstract
EphB receptor tyrosine kinases are enriched at synapses, suggesting that th ese receptors play a role in synapse formation or function. We find that Ep hrinB binding to EphB induces a direct interaction of EphB with NMDA-type g lutamate receptors. This interaction occurs at the cell surface and is medi ated by the extracellular regions of the two receptors, but does not requir e the kinase activity of EphB. The kinase activity of EphB may be important for subsequent steps in synapse formation, as perturbation of EphB tyrosin e kinase activity affects the number of synaptic specializations that form in cultured neurons. These findings indicate that EphrinB activation of Eph B promotes an association of EphB with NMDA receptors that may be critical for synapse development or function.