M. Jerzak et al., Intravenous immunoglobulin therapy influences T cell adhesion to extracellular matrix in women with a history of recurrent spontaneous abortions, AM J REPROD, 44(6), 2000, pp. 336-341
PROBLEM: To determine activated T cell adhesion level to extracellular matr
ix (ECM) in non-pregnant women with a history of recurrent spontaneous abor
tions (RSA). In addition, to evaluate a small-dose intravenous immunoglobul
in (IVIG) therapy influences on T cell adhesion to ECM.
METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA)
activated T cell adhesion to the following extracellular matrix proteins:
collagen IV, fibronectin and elastin were studied in women with the history
of RSA. In addition, IVIG immunotherapy influence on T cell adhesion was s
tudied. Normal T cells adhesion values were established in non-pregnant hea
lthy women with the previous successful pregnancy outcome and in normal hea
lthy pregnant women.
RESULTS: PHA activated T cell adhesion to collagen IV (P=0.04), fibronectin
(P = 0.0003) nad elastin (P = 0.02) were significantly higher in women wit
h the history of RSA when compared to non-pregnant healthy women wit the pr
evious successful pregnancy outcome. IVIG immunotherapy normalized the T ce
ll adhesion level and favored a successful pregnancy.
CONCLUSIONS: Increased T cell adhesion to collagen IV, fibronectin and elas
tin characterize women with the history of RSA. Decreased T cell adhesion t
o the main extracellular matrix components of human placenta may underlie p
ossible effect of IVIG action.