Intravenous immunoglobulin therapy influences T cell adhesion to extracellular matrix in women with a history of recurrent spontaneous abortions

Citation
M. Jerzak et al., Intravenous immunoglobulin therapy influences T cell adhesion to extracellular matrix in women with a history of recurrent spontaneous abortions, AM J REPROD, 44(6), 2000, pp. 336-341
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
44
Issue
6
Year of publication
2000
Pages
336 - 341
Database
ISI
SICI code
1046-7408(200012)44:6<336:IITITC>2.0.ZU;2-4
Abstract
PROBLEM: To determine activated T cell adhesion level to extracellular matr ix (ECM) in non-pregnant women with a history of recurrent spontaneous abor tions (RSA). In addition, to evaluate a small-dose intravenous immunoglobul in (IVIG) therapy influences on T cell adhesion to ECM. METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA) activated T cell adhesion to the following extracellular matrix proteins: collagen IV, fibronectin and elastin were studied in women with the history of RSA. In addition, IVIG immunotherapy influence on T cell adhesion was s tudied. Normal T cells adhesion values were established in non-pregnant hea lthy women with the previous successful pregnancy outcome and in normal hea lthy pregnant women. RESULTS: PHA activated T cell adhesion to collagen IV (P=0.04), fibronectin (P = 0.0003) nad elastin (P = 0.02) were significantly higher in women wit h the history of RSA when compared to non-pregnant healthy women wit the pr evious successful pregnancy outcome. IVIG immunotherapy normalized the T ce ll adhesion level and favored a successful pregnancy. CONCLUSIONS: Increased T cell adhesion to collagen IV, fibronectin and elas tin characterize women with the history of RSA. Decreased T cell adhesion t o the main extracellular matrix components of human placenta may underlie p ossible effect of IVIG action.