Enantioselective synthesis of (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butyramide, a key intermediate for 20(S)-camptothecin analogues, via asymmetric bromolactonization

Citation
Ss. Jew et al., Enantioselective synthesis of (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butyramide, a key intermediate for 20(S)-camptothecin analogues, via asymmetric bromolactonization, TETRAHEDR-A, 11(19), 2000, pp. 3985-3994
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
0957-4166 → ACNP
Volume
11
Issue
19
Year of publication
2000
Pages
3985 - 3994
Database
ISI
SICI code
0957-4166(20001006)11:19<3985:ESO(>2.0.ZU;2-D
Abstract
A new enantioselective synthetic method for enantiomerically pure (S)-N,N-d iethyl-2-formyl-2(methoxymethoxy)butyramide 5, a versatile key intermediate has been developed employing asymmetric bromolactonization using (S)-proli ne as the chiral auxiliary. (C) 2000 Elsevier Science Ltd. All rights reser ved.