Enantioselective synthesis of (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butyramide, a key intermediate for 20(S)-camptothecin analogues, via asymmetric bromolactonization
Ss. Jew et al., Enantioselective synthesis of (S)-N,N-diethyl-2-formyl-2-(methoxymethoxy)butyramide, a key intermediate for 20(S)-camptothecin analogues, via asymmetric bromolactonization, TETRAHEDR-A, 11(19), 2000, pp. 3985-3994
A new enantioselective synthetic method for enantiomerically pure (S)-N,N-d
iethyl-2-formyl-2(methoxymethoxy)butyramide 5, a versatile key intermediate
has been developed employing asymmetric bromolactonization using (S)-proli
ne as the chiral auxiliary. (C) 2000 Elsevier Science Ltd. All rights reser
ved.