Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract

Citation
J. Wang et al., Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract, CHIN MED J, 113(11), 2000, pp. 1036-1039
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
CHINESE MEDICAL JOURNAL
ISSN journal
0366-6999 → ACNP
Volume
113
Issue
11
Year of publication
2000
Pages
1036 - 1039
Database
ISI
SICI code
0366-6999(200011)113:11<1036:CAOAOT>2.0.ZU;2-J
Abstract
Objective To study the clinicopathologic features; and immunoprofile of ang iomyofibroblastoma (AMF) with emphasis an differential diagnosis. Methods Seven vulvar, two vaginal and one perineal angiomyofibroblastomas w ere evaluated by light microscopy and immunohistochemistry. The immunohisto chemical studies were performed on paraffin-embedded sections using the sta ndard ABC method with a panel of antibodies. Results Angiomyofibroblastoma predominantly occurred in middle-aged women i n the genital region, especially in the superficial area of the vulva. Clin ically, most of the tumors presented as slowly growing painless masses and were often diagnosed as Bartholin's gland. cysts. Histologically, the tumor s were all well-circumscribed and characterized by alternating hypocellular and hypercellular areas with abundant thin-walled blood vessels. The tumor cells were bland and spindle-shaped or epithelioid and tended to concentra te around the vessels or cluster in small nests. Immunohistochemically, the tumor cells expressed vimentin and estrogen receptor protein in ail 10 cas es and desmin in 9 cases. Three cases showed weak or focal immunoreactivity to alpha-smooth muscle actin and muscle specific actin. All ten patients w ere treated by local excision. Follow-up showed a benign course with no sig ns of recurrence. Conclusions Angiomyofibroblastoma is a distinctive neoplasm that has a prop ensity to occur in the female genital tract. Recognition of this entity is important to avoid misdiagnosis with other vulvar angiomyxoid neoplasms.