Objective To study the clinicopathologic features; and immunoprofile of ang
iomyofibroblastoma (AMF) with emphasis an differential diagnosis.
Methods Seven vulvar, two vaginal and one perineal angiomyofibroblastomas w
ere evaluated by light microscopy and immunohistochemistry. The immunohisto
chemical studies were performed on paraffin-embedded sections using the sta
ndard ABC method with a panel of antibodies.
Results Angiomyofibroblastoma predominantly occurred in middle-aged women i
n the genital region, especially in the superficial area of the vulva. Clin
ically, most of the tumors presented as slowly growing painless masses and
were often diagnosed as Bartholin's gland. cysts. Histologically, the tumor
s were all well-circumscribed and characterized by alternating hypocellular
and hypercellular areas with abundant thin-walled blood vessels. The tumor
cells were bland and spindle-shaped or epithelioid and tended to concentra
te around the vessels or cluster in small nests. Immunohistochemically, the
tumor cells expressed vimentin and estrogen receptor protein in ail 10 cas
es and desmin in 9 cases. Three cases showed weak or focal immunoreactivity
to alpha-smooth muscle actin and muscle specific actin. All ten patients w
ere treated by local excision. Follow-up showed a benign course with no sig
ns of recurrence.
Conclusions Angiomyofibroblastoma is a distinctive neoplasm that has a prop
ensity to occur in the female genital tract. Recognition of this entity is
important to avoid misdiagnosis with other vulvar angiomyxoid neoplasms.