Transfection of the plasma-type platelet-activating factor acetylhydrolasegene attenuates glutamate-induced apoptosis in cultured rat cortical neurons

Citation
Y. Hirashima et al., Transfection of the plasma-type platelet-activating factor acetylhydrolasegene attenuates glutamate-induced apoptosis in cultured rat cortical neurons, BRAIN RES, 885(1), 2000, pp. 128-132
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
0006-8993 → ACNP
Volume
885
Issue
1
Year of publication
2000
Pages
128 - 132
Database
ISI
SICI code
0006-8993(200012)885:1<128:TOTPPF>2.0.ZU;2-2
Abstract
Using an adenoviral vector, we induced overexpression of the plasma type of platelet-activating factor acetylhydrolase in cultured rat neurons. Neuron s overexpressing this enzyme showed a decrease in glutamate-induced injury, mainly, apparent as decreased apoptosis. Reduction of lipid peroxidation b y this enzyme and protection of mitochondrial function were demonstrated, a nd these may be the basis of the resistance to glutamate-induced neuronal i njury that we observed. (C) 2000 Elsevier Science B.V. All rights reserved.