Morphological change of substance P receptor immunoreactive dendrites of preganglionic sympathetic neurons

Citation
S. Ohtori et al., Morphological change of substance P receptor immunoreactive dendrites of preganglionic sympathetic neurons, ANN ANATOMY, 182(6), 2000, pp. 509-513
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
ISSN journal
0940-9602 → ACNP
Volume
182
Issue
6
Year of publication
2000
Pages
509 - 513
Database
ISI
SICI code
0940-9602(200011)182:6<509:MCOSPR>2.0.ZU;2-H
Abstract
Substance P (SP)-containing terminals and SP receptors (SPRs) are found on the dendrites of preganglionic sympathetic neurons (PSNs) in the intermedio -lateral nucleus (IML) of the spinal cord. The SP-containing fibers were th ought to be of supraspinal origin. However, the primary sensory nerve fiber s terminated around PSNs, and some of them directly on PSNs. We observed ap proximately 150 SPR-immunoreactive (ir) varicosities on the dendrites of PS Ns in slices of the first thoracic segment (T1) in control rats. The number of varicosities decreased to 41% 14 days after hemisection of the spinal c ord at the fourth cervical segment (C4), and to 55% 14 days after sectionin g the spinal dorsal roots at the C8 and T1 levels. The number of varicositi es decreased by 33% in 8-week-old rats which had been administered capsaici n subcutaneously within 24 hours after birth to eradicate unmyelinated sens ory fibers. However, varicosities increased by 15% 15 minutes after injecti on of capsaicin into the plantar surface of the front paw to stimulate soma tosensory nerve fibers in adult rats. The results demonstrate that SPR-ir v aricosities on the dendrites of PSNs were modulated not only by the suprasp inal nervous system but also directly by the primary sensory nerve terminal s.