Whipple's disease with normal intestinal histology: rarity or reality

Citation
R. Hirsbrunner-erni et al., Whipple's disease with normal intestinal histology: rarity or reality, SCHW MED WO, 130(47), 2000, pp. 1820-1826
Citations number
25
Language
TEDESCO
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT
ISSN journal
0036-7672 → ACNP
Volume
130
Issue
47
Year of publication
2000
Pages
1820 - 1826
Database
ISI
SICI code
0036-7672(20001125)130:47<1820:WDWNIH>2.0.ZU;2-V
Abstract
Whipple's disease has been diagnosed more frequently in recent years as a c onsequence of better awareness and of improved diagnostic tools. The number of case reports of Whipple's disease without gastrointestinal symptoms and without histological lesions of the intestinal mucosa is increasing. There fore, the traditional perception of this disease as well as the methods for its diagnosis need to be revised. We report on 2 patients with Whipple's d isease who had systemic inflammatory reactions but neither gastrointestinal symptoms nor an abnormal duodenal histology. Whipple's disease was diagnos ed on the basis of extraintestinal tissue histology (lymph node, vertebral body) and by polymerase chain reaction, and was treated successfully with a ntibiotics. Recommendations for diagnostic procedure in Whipple's disease w ith both typical and atypical clinical presentation are discussed.