Transcriptional regulation of cardiac development: Implications for congenital heart disease and DiGeorge syndrome

Citation
Ja. Epstein et Ca. Buck, Transcriptional regulation of cardiac development: Implications for congenital heart disease and DiGeorge syndrome, PEDIAT RES, 48(6), 2000, pp. 717-724
Citations number
111
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
PEDIATRIC RESEARCH
ISSN journal
0031-3998 → ACNP
Volume
48
Issue
6
Year of publication
2000
Pages
717 - 724
Database
ISI
SICI code
0031-3998(200012)48:6<717:TROCDI>2.0.ZU;2-D
Abstract
In recent years, impressive advances have occurred in our understanding of transcriptional regulation of cardiac development. These insights have begu n to elucidate the mystery of congenital heart disease at the molecular lev el. In addition, the molecular pathways emerging from the study of cardiac development are being applied to the understanding of adult cardiac disease . Preliminary results support the contention that a thorough understanding of molecular programs governing cardiac morphogenesis will provide importan t insights into the pathogenesis of human cardiac diseases. This review wil l focus on examples of transcription factors that play critical roles at va rious phases of cardiac development and their relevance to cardiac disease. This is an exciting and burgeoning area of investigation. It is not possib le to be all-inclusive, and the reader will note important efforts in the a reas of cardiomyocyte determination, left-right asymmetry, cardiac muscular dystrophies, electrophysiology and vascular disease are not covered. For a more complete discussion, the reader is referred to recent reviews includi ng the excellent compilation of observations assembled by Harvey and Rosent hal (1).